Tissue-dependent alterations in lipid mass in mice lacking glycerol kinase
AbstractGlycerol kinase (ATP:glycerol-3-phosphotransferase, EC 2.7.1.30, glycerokinase) (Gyk) has a central role in plasma glycerol extraction and utilization by tissues for lipid biosynthesis. Gyk...
View ArticleErucic Acid is Differentially Taken up and Metabolized in Rat Liver and Heart
AbstractBecause X-linked adrenoleukodystrophy is treated using erucic acid (22:1n-9), we assessed its metabolism in rat liver and heart following infusion of [14-14C]22:1n-9 (170 Ci/kg) under...
View ArticleThe role of α-synuclein in brain lipid metabolism: a downstream impact on...
Abstractα-Synuclein (Snca) is an abundant small cytosolic protein (140 amino acids) that is expressed in the brain, although its physiological role is poorly defined. Consistent with its ubiquitous...
View ArticleLack of Alpha-Synuclein Modulates Microglial Phenotype In Vitro
AbstractAlpha (α)-synuclein neuronal effects are continually being defined although its role in regulating glial phenotypes remains unclear. An ability to regulate microglial activation was...
View ArticleA Fast One-Step Extraction and UPLC–MS/MS Analysis for E 2 /D 2 Series...
AbstractProstaglandins (PG) and isoprostanes (iso-PG) may be derived through cyclooxygenase or free radical pathways and are important signaling molecules that are also robust biomarkers of oxidative...
View ArticleAlterations in Membrane Phospholipid Fatty Acids of Gram-Positive...
AbstractPressure is an important thermodynamic property of the ocean and the deep biosphere that affects microbial physiology and biochemistry. Here, we report on our investigation of the response of...
View ArticleNovel Very Long-Chain α-Methoxylated Δ5,9 Fatty Acids from the Sponge...
AbstractThe novel fatty acids (2R,5Z,9Z)-2-methoxy-25-methyl-5,9-hexacosadienoic acid (1a) and (2R,5Z,9Z)-2-methoxy-24-methyl-5,9-hexacosadienoic acid (1b) were isolated in 80 % purity from the...
View ArticleBrain 2-Arachidonoylglycerol Levels Are Dramatically and Rapidly Increased...
AbstractThe involvement of brain 2-arachidonoylglycerol (2-AG) in a number of critical physiological and pathophysiological regulatory mechanisms highlights the importance for an accurate brain 2-AG...
View ArticleMicroenvironment-sensing, nanocarrier-mediated delivery of combination...
AbstractLimited effectiveness of Raf and MEK inhibitors has impelled the interest to use the inhibitors of Extra-cellular Receptor Kinase (ERK) pathway in combination with Gemcitabine (GEM) in...
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